Mental health is a large component of one's overall health. Mental health is a trending topic that has still lacked the research it needs to match the improving practices of the rest of modern healthcare. We decided to narrow our search on the population of adolescents. Depression is the leading cause of illness and disability among adolescents, and suicide is the second leading cause of adolescent death (WHO). According to WHO, "half of all mental health disorders start by age 14, but most cases are undetected and untreated." Prevalence of depression in adolescents has increased over the years despite there being many different methods of treatment. A literature review was conducted utilizing databases such as Google Scholar, CINAHL, and Ebscohost with a focus of looking at the effectiveness between SSRIs, SNRIs, and CBT in treating adolescent depression.