This ethnographic research was conducted in the Northeastern U.S. to investigate factors influencing wellness/well-being among Muslim American children in this region from their mothers' perspectives, and to explore how Muslim mothers mediate challenges faced by their children in order to support their children's well-being. Data were collected via semi-structured interviews with seven Muslim mothers from different countries, observation, and field notes. The ecological model and Hettler's definition of wellness were used as frameworks for understanding Muslim mothers' experiences. Using thematic analysis, two categories of themes emerged as research questions: 1) factors impacting wellness/well-being (discrimination, cultural friction, apprehension and fear, lack of awareness of Islam, and misalignment of organizational processes); and 2) mother's methods of mediating their children's challenges (nurturing, cultural accommodation, and acceptable adaptations within family practices. The study identifies its limitations and implications for future research.